I do not believe that this is as much a  hard question to answer as it is a hard question to accept.  We all see God as a loving God.  We understand that He wants all men everywhere to be saved (1 Timothy 2:4).  God is a loving God, but such love demands justice (Romans 3:26).  God has set standards that all men must accept, and those who are in remote areas are just as amenable to God’s law as those who fill church pews here in America.  II Thessalonians 1:8 removes any doubt as to the answer of the above question, “In flaming fire taking vengeance on them that know not God, and that obey not the gospel of our Lord Jesus Christ.”  The answer to the above question is simply “yes,” so the emphasis of this article will shift to the “why” aspect of the matter:  Why will those in remote areas be lost?
    I can think of two reasons, the first involving hind sight and the second involving foresight.  Just as we have the responsibility of obeying God today, so all men of all times have had that responsibility.  That was true in the garden of Eden, in the Mosaical age, in the first century and is likewise true in this day.  It is a principal that universally transcends time and space.  Suppose that over time America ceases to be a Christian nation and God’s people slowly fade from this nation’s history.  The result would be generations of people who are separated from God because He was rejected by their forefathers.  Without mission efforts to reach them they would be lost, even those who never even heard about God.  Note that this is not the doctrine of original sin (they are not born in sin but are reared in a Godless society), but understand that there are repercussions when people on individual and national levels forget about God.  This principle is taught in Numbers 14:18 and other like verses, “The Lord is longsuffering, and of great mercy, forgiving iniquity and transgression, and by no means clearing the guilty, visiting the iniquity of the fathers upon the children unto the third and fourth generation.”  Translate this to those who are in remote areas today.  They will be lost because somewhere in their past their fore fathers rejected God.
    The second reason that those in remote areas who have never heard the Gospel of Christ will be lost is due to the fact that those who are faithful Christians have failed to reach out to them.  In Matthew 28:19,20; Mark 16:15,16, and Luke 24:46,47 the great commission is given.  It is a commission first to the apostles, and really to all Christians, to spread the Gospel throughout the world.  With this responsibility on us it behooves us to teach the Gospel to all using whatever authorized means are available.  When we appear before the throne of God in judgement we will have to answer for the souls of those who were not reached, that is we will have to have made some effort to reach them.  Now what if those are not lost?  If those who have not heard are not going to be lost why should we teach them a message that if heard and rejected will condemn them?  The answer is simple:  They stand condemned now and we must teach them the message that if heard and received (through obedience) will save them.